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Arthrogryposis

DA: 37




Developmental anomaly information

Definition: Arthrogryposis, or arthrogryposis multiplex congenita (AMC), comprises nonprogressive conditions characterized by multiple joint contractures found throughout the body at birth. The term is currently used in connection with a very heterogeneous group of disorders that all include the common feature of multiple congenital joint contractures The major cause of arthrogryposis is fetal akinesia. During early embryogenesis, joint development is almost always normal. Motion is essential for the normal development of joints and their contiguous structures; lack of fetal movement causes extra connective tissue to develop around the joint. This results in fixation of the joint, limiting movement and further aggravating the joint contracture. Contractures secondary to fetal akinesia are more severe in patients in whom the diagnosis is made early in pregnancy and in those who experience akinesia for longer periods of time during gestation.


Synonyms:

  • Arthrogryposis multiplex congenita
  • Articular contraction of the limbs, fetal


Developmental anomaly parent: Akinesia, fetal

Topology: Human body > Limbs

System: Human body > musculoskeletal system. > Joints

Developmental anomaly category: Deformity ( mechanical factor) sequence

Case records MDB55, MDB193, MDB230, MDB238, MDB337, MDB392, MDB401, MDB406, MDB450, MDB461, MDB110, MDB479, MDB485, MDB511, MDB520, MDB522, MDB543, MDB257, MDB329, MDB409
Links

Humpath: 1266

Observed in MDB cases
Observed in combinaisons (MDB)
Observed in malformative diseases (MDB)
Associated genes in profile
Associated genes in malformative diseases
Associated chromosomal diseases
Associated signaling pathways
Associated developmental anomalies

Here is the list of developmental anomalies associated with this developmental anomaly, based on the cases' information :



Last modified: 2009-01-07 17:22:55 by farideh

Created: 2008-02-22 01:00:00 by phsaw



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