View a developmental anomaly category

Developmental anomaly categoryinformation for Association

Description: An assosiation is a nonrandom occurance in two or more individuals of multiple anomalies not known to be a polytopic field defect, sequence, or syndrome. Association refers solely to statistically, not pathogenetically or causally related anomalies.


Developmental anomalies associated with this developmental anomaly category :

Array
(
    [Dacategory] => Array
        (
            [id] => 23
            [name] => Association
            [description] => An assosiation is a nonrandom occurance in two or more individuals of multiple anomalies not known to be a polytopic field defect, sequence, or syndrome. Association refers solely to statistically, not pathogenetically or causally related anomalies.
        )

    [Thesaurus] => Array
        (
            [0] => Array
                (
                    [id] => 127
                    [name] => 
                    [description] => CHARGE syndrome was initially defined as a non-random association of anomalies (Coloboma, Heart defect, Atresia choanae, Retarded growth and development, Genital hypoplasia, Ear anomalies/deafness). In 1998, an expert group defined the major (the classical 4C's: Choanal atresia, Coloboma, Characteristic ears and Cranial nerve anomalies) and minor criteria of CHARGE syndrome. Individuals with all four major characteristics or three major and three minor characteristics are highly likely to have CHARGE syndrome.
In 2004 a Netherlands study (Vissers, LELM, et.al) found a gene (CHD7 on 8Q12) which was implicated in 2/3 of those tested.  This gene is responsible for encoding a number of DNA protein which is esential when neural crest cells are being formed and migrating.  A negative genetic test for changes in the CHD7 gene can still result in a diagnosis of CHARGE
                    [author_id] => 3
                    [topo_code] => 
                    [category_code] => 23
                    [system_code] => 
                    [parent_da_code] => 0
                    [adicap_ref] => 
                    [humpath_ref] => 
                    [omim_ref] => 
                    [possum_ref] => 
                    [snomed_ref] => 
                    [ICD10_ref] => 
                    [orphanet_ref] => 
                    [emedicine_ref] => 
                    [diseasesdb_ref] => 
                    [mesh_ref] => 
                    [fetusnet_ref] => 
                    [wiki_ref] => 
                    [created] => 2008-03-17 01:00:00
                    [modified] => 2010-10-29 16:31:46
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 1
                )

            [1] => Array
                (
                    [id] => 635
                    [name] => 
                    [description] =>  This association involves:
V -- vertebral anomalies / dysgenesis, vascular anomalies 
A -- anal atresia 
C -- Cardiac anomalies 
T -- tracheo-esophageal (T-E) fistula 
E -- esophageal atresia 
R -- renal anomalies, radial dysplasia 
L -- Limb anomalies 
S -  Single umbilical artery
Lubinskyet al.have suggested that all the VATER associations present disruption sequences, as exemplified in the common metabolic disruptive condition of maternal diabetes in infants with VATER association.
 


                    [author_id] => 3
                    [topo_code] => 1
                    [category_code] => 23
                    [system_code] => 1
                    [parent_da_code] => 0
                    [adicap_ref] => 
                    [humpath_ref] => 
                    [omim_ref] => 
                    [possum_ref] => 
                    [snomed_ref] => 
                    [ICD10_ref] => 
                    [orphanet_ref] => 
                    [emedicine_ref] => 
                    [diseasesdb_ref] => 
                    [mesh_ref] => 
                    [fetusnet_ref] => 
                    [wiki_ref] => 
                    [created] => 2008-08-27 19:57:12
                    [modified] => 2009-05-14 19:08:06
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 1
                )

        )

)