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Developmental anomaly categoryinformation for Deformity ( mechanical factor) sequence

Description: Arthrogryposis is an example of sequence caused by a mechanical factor, i.e. intrauterine limitation of fetal movement( Fetal Akinesia Deformation Sequence).


Developmental anomalies associated with this developmental anomaly category :

Array
(
    [Dacategory] => Array
        (
            [id] => 18
            [name] => Deformity ( mechanical factor) sequence
            [description] => Arthrogryposis is an example of sequence caused by a mechanical factor, i.e. intrauterine limitation  of fetal movement( Fetal Akinesia Deformation Sequence).
        )

    [Thesaurus] => Array
        (
            [0] => Array
                (
                    [id] => 37
                    [name] => Arthrogryposis
                    [description] => Arthrogryposis, or arthrogryposis multiplex congenita (AMC), comprises nonprogressive conditions characterized by multiple joint contractures found throughout the body at birth. The term is currently used in connection with a very heterogeneous group of disorders that all include the common feature of multiple congenital joint contractures
The major cause of arthrogryposis is fetal akinesia. 
During early embryogenesis, joint development is almost always normal. Motion is essential for the normal development of joints and their contiguous structures; lack of fetal movement causes extra connective tissue to develop around the joint. This results in fixation of the joint, limiting movement and further aggravating the joint contracture. Contractures secondary to fetal akinesia are more severe in patients in whom the diagnosis is made early in pregnancy and in those who experience akinesia for longer periods of time during gestation.


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                    [system_code] => 45
                    [parent_da_code] => 478
                    [adicap_ref] => 
                    [humpath_ref] => 1266
                    [omim_ref] => 
                    [possum_ref] => 
                    [snomed_ref] => 
                    [ICD10_ref] => Q74.3 
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                    [fetusnet_ref] => 
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                    [created] => 2008-02-22 01:00:00
                    [modified] => 2009-01-07 17:22:55
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 0
                )

            [1] => Array
                (
                    [id] => 178
                    [name] => Potter deformity sequence
                    [description] => Severe and prolonged oligohydramnios leads to a constellation of findings that include Potter's facies (flattened nose, recessed chin, and low-set ears) and positional abnormalities (clubbed feet, dislocated hips, and contractures).Fetus with Potter sequence usaully has pulmonary hypoplasia.
                    [author_id] => 1
                    [topo_code] => 1
                    [category_code] => 18
                    [system_code] => 1
                    [parent_da_code] => 0
                    [adicap_ref] => 
                    [humpath_ref] => 11385
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                    [created] => 2008-05-09 02:00:00
                    [modified] => 2008-12-15 16:00:34
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 0
                )

            [2] => Array
                (
                    [id] => 323
                    [name] => Pena Shokeir syndrome , Type I
                    [description] => Pena-Shokeir syndrome is an inherited disorder characterized by neurogenic arthrogryposis, facial anomalies, pulmonary hypoplasia and dysmorphic features resulting from fetal akinesia. Absent or reduced fetal movement leads to stiff joints, pterygia, and abnormal neuromuscular function with decreased fetal swallowing, which causes pulmonary hypoplasia and polyhydramnios.
Autosomal-recessive is the most common pattern of transmission. Several descriptions of unusual presentations suggest a heterogenic etiology.

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                    [omim_ref] => 208150
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                    [created] => 2008-06-02 02:00:00
                    [modified] => 2008-12-02 17:39:09
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 0
                )

            [3] => Array
                (
                    [id] => 642
                    [name] => overlapping skull bones
                    [description] => 
                    [author_id] => 3
                    [topo_code] => 46
                    [category_code] => 18
                    [system_code] => 44
                    [parent_da_code] => 0
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                    [created] => 2008-08-27 22:48:54
                    [modified] => 2008-12-04 16:00:32
                    [modified_by] => 3
                    [test] => 0
                    [isFree] => 0
                )

        )

)