Diandric triploidy

SYD: 33




Diandric triploidy

Description: Diandric triploidy can result from fertilization of a haploid ovum by either a diploid sperm, or by two haploid sperm and can result in a XXX, XXY, or XYY genotype. The majority of triploid cases are of paternal origin, with 66% attributed to fertilization by two sperm, 24% due to fertilization with a diploid sperm, and 10% resulting from fertilization of a diploid oocyte. Phenotypically, diandric triploidy conceptuses are associated with an enlarged placenta that is histology consistent with a partial hydatidiform mole. In the case described above, the triploid conceptuses occurred in subsequent pregnancies, and neither showed evidence of a partial hydatidiform mole suggesting that the triploidy was attributable to maternal origin. A suggested maternal mechanism resulting in triploidy is nondisjunction in meiosis I or meiosis II of oogenesis.


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Developmental anomalies

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There are no developmental anomalies for this combination.

Observed in MDB cases:


There are no developmental anomalies for this combination.
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