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Congenital anomalies of the kidney and urinary tract (CAKUT)

DA: 857




Developmental anomaly information

Definition: Congenital anomalies of the kidney and urinary tract (CAKUT) make up a family of diseases with a diverse anatomic spectrum, including kidney anomalies (e.g., renal dysplasia, duplex kidney, and hydronephrosis) and ureter anomalies (e.g., vesicoureteral reflux, megaureter, and ureterovesical junction (UVJ) obstruction).Vesicoureteral reflux (VUR, OMIM 193000), one of the most common manifestations of CAKUT, with an incidence of approximately 1 in 100 infants, is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections (Lu et al., 2007). Primary VUR results from a developmental defect of the ureterovesical junction (UVJ). In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy (RN).


Synonyms:

  • CAKUT


Developmental anomaly parent: (empty)

Topology: Human body > Abdomen > Retroperitoneum > Kidneys

System: Human body > Urinary system

Developmental anomaly category: Malformation

Case records
Links

OMIM: 193000

Observed in MDB cases
Observed in combinaisons (MDB)
Observed in malformative diseases (MDB)
Associated genes in profile
Associated genes in malformative diseases
Associated chromosomal diseases
Associated signaling pathways
Associated developmental anomalies

Last modified: 2008-12-29 16:16:42 by farideh

Created: 2008-12-29 16:12:17 by farideh



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