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Arnold-Chiari Type II malformation (CM II)

DA: 62

Developmental anomaly information

Definition: Chiari type II malformation (CMII) is one of three hindbrain malformations that display hydrocephalus.In this case, the cerebellum and a portion of the brainstem are displaced into the spinal canal. CM II, is a unique hindbrain herniation found only in patients with myelomeningocele. Arnold-Chiari type II malformation may impede CSF flow and cause hydrocephalus, which occurs in more than 90% of infants with myelomeningocele(particularly after treatment of the myelomeningocele). Cerebral cortex dysplasia, including cerebral heterotopias, polymicrogyria, abnormal lamination, fused thalami, and corpus callosum abnormalities, are other anomalies often associated with Arnold-Chiari type II malformations.


  • Arnold-Chiari malformation
  • Classic CM
  • Cerebellomedullary Malformation Syndrome

Developmental anomaly parent: (empty)

Topology: Human body > Head and neck > Head > Cranium > Brain

System: Human body > Nervous system > Central nervous system

Developmental anomaly category: Malformation

Case records MDB43, MDB58, MDB187, MDB193, MDB220, MDB253, MDB256, MDB288, MDB366, MDB370, MDB378, MDB383, MDB397, MDB31, MDB417, MDB439, MDB445, MDB447, MDB507, MDB517, MDB542, MDB457

Humpath: 13365

Observed in MDB cases
Observed in combinaisons (MDB)
Observed in malformative diseases (MDB)
Associated genes in profile
Associated genes in malformative diseases
Associated chromosomal diseases
Associated signaling pathways
Associated developmental anomalies

Here is the list of developmental anomalies associated with this developmental anomaly, based on the cases' information :

Last modified: 2008-12-23 20:52:36 by farideh

Created: 2008-02-25 01:00:00 by phsaw

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