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Myelomeningocele,lumbosacral with hydrocephalus

DA: 159

Developmental anomaly information

Definition: Myelomeningocele (Open NTD,ONTD )is classified as a teratogenic process that results in a failed closure and abnormal differentiation of the embryonic neural tube during the first 4 weeks of gestation. Abnormal development of the posterior caudal neural tube produces a myelodysplasia. The defect can occur anywhere from the base of the skull to sacrum. The anatomic level of the spinal cord lesion roughly correlates with the patient's neurologic deficit. Developmental abnormality of the cephalic anterior tube gives rise to several CNS anomalies, including Arnold-Chiari type II malformation characterized by cerebellar hypoplasia and varying degrees of caudal displacement of the hindbrain into the upper cervical canal through a widened foramen magnum. Arnold-Chiari type II malformation may impede CSF flow and cause hydrocephalus, which occurs in more than 90% of infants with myelomeningocele(particularly after treatment of the myelomeningocele). Cerebral cortex dysplasia, including cerebral heterotopias, polymicrogyria, abnormal lamination, fused thalami, and corpus callosum abnormalities, are other anomalies often associated with Arnold-Chiari type II malformations.

Developmental anomaly parent: Spina bifida cystica (aperta)

Topology: Human body > Abdomen > Spine > Spinal cord

System: Human body > Nervous system > Central nervous system > Spinal cord

Developmental anomaly category: Dysraphism

Case records MDB31, MDB187, MDB174, MDB180, MDB241, MDB356, MDB417, MDB445, MDB256, MDB288, MDB303, MDB507, MDB542
Observed in MDB cases
Observed in combinaisons (MDB)
Observed in malformative diseases (MDB)
Associated genes in profile
Associated genes in malformative diseases
Associated chromosomal diseases
Associated signaling pathways
Associated developmental anomalies

Here is the list of developmental anomalies associated with this developmental anomaly, based on the cases' information :

Last modified: 2008-12-23 21:18:00 by farideh

Created: 2008-05-08 02:00:00 by phsaw

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